Management of hyperthyroidism in children. Issue 4 (3rd July 2016)

• Record Type: Journal Article
• Authors: De Luca, Filippo; Salzano, Giuseppina; Zirilli, Giuseppina; Calafiore, Mariarosa; Corica, Domenico; Sferlazzas, Concetta
• Is Part Of: Expert review of endocrinology & metabolism. Volume 11:Issue 4(2016)
• Page Start: 301
• Page End: 309
• Publication Date: 2016-07-03
• Subjects: Fetal and neonatal hypothyroidism -- Graves' disease -- Hashitoxicosis -- hyperfunctioning thyroid nodules -- McCune Albright syndrome -- methimazole treatment -- radioiodine therapy -- resistance to thyroid hormones -- total thyroidectomy -- TSH-secreting pituitary adenoma; Endocrinology -- Periodicals; Metabolism -- Periodicals; 616.4
• DOI: 10.1080/17446651.2016.1199953
• Languages: English
• ISSNs: 1744-6651

Abstract

ABSTRACT: Introduction : Treatment of hyperthyroidism in children differs according to its etiology; in particular, the optimal therapy of Graves' disease (GD) remains a matter of debate and there is currently no evidence-based therapeutic strategy that is universally adopted in all the countries. Areas covered : The most recent treatment strategies in the different pediatric conditions which may be associated with hyperthyroidism. We searched PubMed and Cochrane (1990 to 2016) in order to identify articles to include in this review using the following terms: Hyperthyroidism, Childhood, Antithyroid drug therapy, Thyroidectomy, Radioactive iodine. Expert commentary : Although pharmacological therapy represents the first-line approach for GD children, we recommend to individualize, as much as possible, the overall therapeutic approach, with no prejudices towards radical therapies, particularly in the cases with frequent relapses. Clinical and laboratory preferential criteria for an individualized therapeutic approach to GD children are given. Treatment procedures for hyperthyroid children without GD are also discussed.