Essential oil of Zygophyllum album inhibits key-digestive enzymes related to diabetes and hypertension and attenuates symptoms of diarrhea in alloxan-induced diabetic rats. (2nd August 2016)

• Record Type: Journal Article
• Authors: Mnafgui, Kais; Kchaou, Mouna; Ben Salah, Hichem; Hajji, Raouf; Khabbabi, Gaddour; Elfeki, Abdelfattah; Allouche, Noureddine; Gharsallah, Neji
• Is Part Of: Pharmaceutical biology. Volume 54:Number 8(2016:Aug.)
• Page Start: 1326
• Page End: 1333
• Publication Date: 2016-08-02
• Subjects: ACE -- amylase -- lipase; Pharmacognosy -- Periodicals; Materia medica, Vegetable -- Periodicals; 615.321
• DOI: 10.3109/13880209.2015.1075049
• Languages: English
• ISSNs: 1388-0209

Abstract

Abstract: Context : Zygophyllum album L.( Zygophyllaceae), commonly known as Bougriba, is widely used to treat diabetes, digestive tract spasm, and hypertension in folk medicine, in Tunisia. Objective : This study investigates the antidiabetic, antidiarrheal, and antihypertensive activities of the leaves of the essential oil from Zygophyllum album (OZA) in alloxan-induced diabetic rats. Materials and methods : The oil was obtained by hydrodistillation and analyzed by GC-MS. Males rats were divided into four groups: control, diabetic-untreated group, diabetic-treated group with acarbose (10 mg/kg), and diabetic-treated rats with OZA (200 mg/kg) for 30 d. Results : At the end of the experimental period, the OZA significantly decreased the activity of α-amylase in pancreas and serum of the diabetic rats by 43% and 38%, respectively, which led to reduce the serum glucose level by 60% and lower of glycated hemoglobin (HbA1c) rate by 17% as compared with untreated diabetic animals. Moreover, the OZA treatment attenuated symptoms of diarrhea, improved lipid disorders, and hypertension through inhibiting the pancreatic lipase and angiotensin-converting enzyme (ACE) activities by 47% and 25%, respectively, in serum of diabetic rats. Conclusion : OZA showed a good effect in the management of diabetes mellitus and exerted preventive action from related hypertension.