Prenatally Diagnosed Aggressive Intracranial Immature Teratoma–Clinicopathological Correlation. (3rd July 2016)

• Record Type: Journal Article
• Authors: Nariai, Hiroki; Price, Dana E.; Jada, Ajit; Weintraub, Lauren; Weidenheim, Karen M.; Gomes, William A.; Levy, Adam S.; Abbott, Rick; Malbari, Fatema
• Is Part Of: Fetal and pediatric pathology. Volume 35:Number 4(2016)
• Page Start: 260
• Page End: 264
• Publication Date: 2016-07-03
• Subjects: Immature teratoma -- congenital brain tumor -- prenatal diagnosis -- MIB1/Ki-67 proliferation index; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.3109/15513815.2016.1172687
• Languages: English
• ISSNs: 1551-3815

Abstract

ABSTRACT: Objective: To describe clinicopathological correlation of congenital intracranial immature teratoma. Methods: A retrospective case analysis from a tertiary medical center. Results: We report a case of an intracranial immature teratoma detected prenatally at 35 weeks of gestation. The tumor showed rapid growth, causing acute hydrocephalus requiring subsequent ventriculoperitoneal shunting. Resective surgery was performed within 2 weeks after birth. The infant died at day of life 29. Histological examination revealed an immature teratoma, with high MIB1/Ki-67 proliferation index. Conclusion/Implications: Intracranial immature teratoma with high MIB1/Ki-67 proliferation index may serve as an independent poor prognostic factor.