Thyroid hormone therapy and procurement of livers from brain-dead donors. (2nd July 2016)

• Record Type: Journal Article
• Authors: Novitzky, Dimitri; Mi, Zhibao; Videla, Luis A.; Collins, Joseph F.; Cooper, David K. C.
• Is Part Of: Endocrine research. Volume 41:Number 3(2016:Aug.)
• Page Start: 270
• Page End: 273
• Publication Date: 2016-07-02
• Subjects: Anti-diuretic hormone -- brain death -- insulin -- levothyroxine -- organ donors -- triiodothyronine; Endocrinology, Experimental -- Periodicals; Endocrinology -- Periodicals; Endocrinology -- Periodicals; Research -- Periodicals; 616.4
• DOI: 10.3109/07435800.2015.1111902
• Languages: English
• ISSNs: 0743-5800

Abstract

ABSTRACT: Hormonal therapy to brain-dead potential organ donors remains controversial. A retrospective study was carried out of hormonal therapy on procurement of organs in 63, 593 donors in whom information on T3 /T4 therapy was available. In 40, 124 donors, T3 /T4 and all other hormonal therapy was recorded. The percentages of all organs procured, except livers, were greater in T3 /T4 -treated donors. Nevertheless, if T3 /T4 therapy had been administered to the donor, liver transplantation was associated with significantly increased graft and recipient survival at 1 month and 12 months. The potential reasons for the lack of effect of T3 /T4 therapy on the number of livers procured are discussed.