Antisynthetase syndrome: Pulmonary computed tomography findings of adult patients with antibodies to aminoacyl-tRNA synthetases. Issue 8 (August 2016)

• Record Type: Journal Article
• Authors: Waseda, Yuko; Johkoh, Takeshi; Egashira, Ryoko; Sumikawa, Hiromitsu; Saeki, Keigo; Watanabe, Satoshi; Matsunuma, Ryo; Takato, Hazuki; Ichikawa, Yukari; Hamaguchi, Yasuhito; Shiraki, Akira; Muro, Yoshinao; Yasui, Masahide; Prosch, Helmut; Herold, Christian; Kasahara, Kazuo
• Is Part Of: European journal of radiology. Volume 85:Issue 8(2016)
• Page Start: 1421
• Page End: 1426
• Publication Date: 2016-08
• Subjects: Antisynthetase syndrome -- Aminoacyl-tRNA synthetases -- Polymyositis -- Dermatomyositis -- Interstitial lung disease; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2016.05.012
• Languages: English
• ISSNs: 0720-048X

Abstract

Abstract: Objectives: To describe the pulmonary CT findings in patients with anti-ARS-antibody-positive interstitial lung disease (anti-ARS-ILD) Methods: The CT findings of 64 patients with anti-ARS-ILD were retrospectively reviewed. The images were retrospectively reviewed independently by 2 chest radiologists, and the final decision on the CT findings was made by a third chest radiologist. Results: There were 16 male and 48 female patients, aged 54.2 ± 13.4 years. Sixteen patients had anti Jo-1, 24 had anti-EJ, 9 had anti-PL-7, 7 had anti-PL-12, 5 had anti-KS, and 3 had anti-OJ antibodies. Overall, 63 patients (98.4%) had CT findings predominantly in the lower lobe; 61 patients (95.3%) showed peripheral opacities, and 47 patients (73.4%) showed peribronchovascular opacities. Ground-glass attenuation, consolidation, and reticulation showed similar distribution patterns. Regarding detailed CT findings, 89.1% of patients had lower volume loss, 76.6% had interlobular septal thickening, and 67.2% had thickening of bronchovascular bundles. The final radiologic diagnoses were as follows: inconsistent with usual interstitial pneumonia (UIP) in 63 patients (98.4%), which included nonspecific interstitial pneumonia (NSIP) in 35 patients (55.6%), organizing pneumonia (OP) in 4 patients (6.3%), and OP with fibrosis in 22 patients (34.9%). Conclusions: The characteristic CT findings of patients with anti-ARS-ILD were areas of ground-glass attenuation and reticulation, predominantly distributed as lower and peribronchovascular lesions, which is compatible with NSIP. One-third of patients showed OP with fibrosis.