Design and development of a dedicated portable gamma camera system for intra-operative imaging. Issue 7 (July 2016)

• Record Type: Journal Article
• Authors: Kaviani, Sanaz; Zeraatkar, Navid; Sajedi, Salar; Akbarzadeh, Afshin; Gorjizadeh, Nahid; Farahani, Mohammad Hossein; Teimourian, Behnoosh; Ghafarian, Pardis; Sabet, Hamid; Ay, Mohammad Reza
• Is Part Of: Physica medica. Volume 32:Issue 7(2016)
• Page Start: 889
• Page End: 897
• Publication Date: 2016-07
• Subjects: Sentinel lymph node (SLN) -- Lymphoscintigraphy -- SURGEOSIGHT-I -- Breast cancer -- Intra-operative gamma camera; Medical physics -- Periodicals; Biophysics -- Periodicals; Biophysics -- Periodicals; Imagerie médicale -- Périodiques; Radiothérapie -- Périodiques; Rayons X -- Sécurité -- Mesures -- Périodiques; Physique -- Périodiques; Médecine -- Périodiques; 610.153
• DOI: 10.1016/j.ejmp.2016.06.004
• Languages: English
• ISSNs: 1120-1797

Abstract

Highlights: We developed a high performance portable gamma camera for radio-guided surgery. Results show 41 kcps for 20% count loss and the energy resolution was 20.6%. The developed system can be used for radiopharmaceutical guided surgery. The system sensitivity was measured as 142 cps/MBq on the collimator surface. Abstract: Purpose: We developed a high performance portable gamma camera platform dedicated to identification of sentinel lymph nodes (SLNs) and radio-guided surgery for cancer patients. In this work, we present the performance characteristics of SURGEOSIGHT-I, the first version of this platform that can intra-operatively provide high-resolution images of the surveyed areas. Methods: At the heart of this camera, there is a 43 × 43 array of pixelated sodium-activated cesium iodide (CsI(Na)) scintillation crystal with 1 × 1 mm 2 pixel size and 5 mm thickness coupled to a Hamamatsu H8500 flat-panel multi-anode (64 channels) photomultiplier tube. The probe is equipped with a hexagonal parallel-hole lead collimator with 1.2 mm holes. The detector, collimator, and the associated front-end electronics are encapsulated in a common housing referred to as head. Results: Our results show a count rate of ∼41 kcps for 20% count loss. The extrinsic energy resolution was measured as 20.6% at 140 keV. The spatial resolution and the sensitivity of the system on the collimator surface was measured as 2.2 mm and 142 cps/MBq, respectively. In addition, the integral and differential uniformity, after uniformity correction, in useful field-of-view (UFOV) were measured 4.5% and 4.6%, respectively. Conclusions: This system can be used for a number of clinical applications including SLN biopsy and radiopharmaceutical-guided surgery.