Association of low serum 25-hydroxyvitamin D levels with the frailty syndrome in Mexican community-dwelling elderly. (2nd January 2016)

• Record Type: Journal Article
• Authors: Gutiérrez-Robledo, Luis Miguel; Ávila-Funes, José Alberto; Amieva, Hélène; Meillon, Céline; Acosta, José Luis; Navarrete-Reyes, Ana Patricia; Torres-Carrillo, Norma; Muñoz-Valle, José Francisco; Torres-Carrillo, Nora Magdalena
• Is Part Of: Aging male. Volume 19:Number 1(2016:Mar.)
• Page Start: 58
• Page End: 63
• Publication Date: 2016-01-02
• Subjects: Frailty syndrome -- vitamin D -- older people; Aging -- Periodicals; Men -- Periodicals; Gerontology -- Periodicals; Men -- Health and hygiene -- Periodicals; Aging -- periodicals; Geriatric -- periodicals; Men -- periodicals; Aged -- periodicals; Aged, 80 and over -- periodicals; 612.67
• DOI: 10.3109/13685538.2015.1105796
• Languages: English
• ISSNs: 1368-5538

Abstract

Abstract: Objective : Since vitamin D is an important regulator of muscle function, the effect of vitamin D deficiency on frailty syndrome has been recently studied. This cross-sectional study aimed to determine the association between 25(OH)-vitamin D levels and frailty status in Mexican community-dwelling elderly. Methods : Sample of 331 community-dwelling elderly aged 70 or older, a subset of those included in the "Coyoacán cohort" were included. 25(OH)-vitamin D assay and frailty status were measured. Results : Mean age was 79.3 years and 54.1% were women. Those classified as frail were more likely to have lower Mini-Mental State Examination score ( p = 0.015), more disability for instrumental activities of daily living ( p < 0.001) and for activities of daily living ( p < 0.001). Serum 25(OH)-vitamin D levels were lower in the frail subgroup when compared with the non-frail one ( p < 0.001). Multivariate logistic regression analyses showed a significant association between intermediate tertile [odds ratios (OR) = 4.13; 95% confidence intervals (CI) 2.00–8.56] or insufficient tertile (OR = 8.95; 95% CI 2.41–33.30) of vitamin D levels and frailty even after adjusting for potential confounders. Conclusion : These results suggest that older adults with low 25(OH)-vitamin D levels are associated with the probability to being frail compared with those with sufficient vitamin D levels.