XRF-measured bone lead (Pb) as a biomarker for Pb exposure and toxicity among children diagnosed with Pb poisoning. (18th May 2016)

• Record Type: Journal Article
• Authors: Specht, Aaron J.; Lin, Yanfen; Weisskopf, Marc; Yan, Chonghuai; Hu, Howard; Xu, Jian; Nie, Linda H.
• Is Part Of: Biomarkers. Volume 21:Number 4(2016)
• Page Start: 347
• Page End: 352
• Publication Date: 2016-05-18
• Subjects: In vivo -- portable -- X-ray fluorescence; Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2016.1139183
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: Childhood lead (Pb) poisoning remains a global issue, especially in industrial areas. In this study, 115 children with average age 5.7 years were recruited as either patient diagnosed with Pb poisoning or controls at Xinhua Hospital in China. The subjects' bone Pb was measured with a K-shell X-ray fluorescence (KXRF) and a portable X-ray fluorescence (XRF) system. A significant correlation between KXRF bone Pb and blood Pb and portable XRF and KXRF measurements were observed. The half-life of blood-lead was calculated to be 9.96 ± 3.92 d. Our results indicate that bone is a useful biomarker for Pb in children.