Association between IL-27 2905T/G genotypes and the risk and survival of cervical cancer: a case-control study. (2nd April 2016)

• Record Type: Journal Article
• Authors: Wang, Guo-Qing; Zhao, Wen-Hui; Zhao, Xi-Xia; Zhang, Jun; Nan, Ke-Jun
• Is Part Of: Biomarkers. Volume 21:Number 3(2016)
• Page Start: 272
• Page End: 275
• Publication Date: 2016-04-02
• Subjects: Cervical cancer -- IL-27 -- single-nucleotide polymorphism -- susceptibility; Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2015.1134665
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: Background : Interleukin-27 (IL-27) has been recognized as a pleiotropic cytokine with both pro- and anti-inflammatory properties. Patients and methods : A case-control study was conducted to investigate the possible associations of IL-27 gene polymorphisms with susceptibility to cervical cancer and clinical outcome. Results : Our results suggested that the IL-27 2905T/G was significantly associated with a decreased risk of cervical cancer. Further analysis showed IL-27 2905T/G genotypes were associated with advanced tumor stages of cervical cancer patients. More interestingly, the IL-27 2905T/G genotypes were statistically significantly associated with the survival in cervical cancer patients. Conclusion : Our results showed that the IL-27 2905T/G genotypes were associated with decreased the susceptibility and development of cervical cancer in Chinese Han population.