Prodrugs for transdermal drug delivery – trends and challenges. (13th September 2016)

• Record Type: Journal Article
• Authors: Ita, Kevin B.
• Is Part Of: Journal of drug targeting. Volume 24:Number 8(2016)
• Page Start: 671
• Page End: 678
• Publication Date: 2016-09-13
• Subjects: Chemical synthesis -- drug delivery -- prodrugs -- transdermal; Drug delivery systems -- Periodicals; Drug Delivery Systems; Vehicles; Drug Administration Routes; Drug Evaluation; 615.7
• DOI: 10.3109/1061186X.2016.1154562
• Languages: English
• ISSNs: 1061-186X

Abstract

Abstract: Prodrugs continue to attract significant interest in the transdermal drug delivery field. These moieties can confer favorable physicochemical properties on transdermal drug delivery candidates. Alkyl chain lengthening, pegylation are some of the strategies used for prodrug synthesis. It is usually important to optimize partition coefficient, water and oil solubilities of drugs. In this review, progress made in the field of prodrugs for percutaneous penetration is highlighted and the challenges discussed.