Significance of high-normal blood pressure during early second trimester for predicting the onset of hypertensive disorders in pregnancy. (2nd April 2016)

• Record Type: Journal Article
• Authors: Mabuchi, Aki; Yamamoto, Ryo; Ishii, Keisuke; Kakubari, Reisa; Takaoka, Sachi; Muto, Haruka; Mitsuda, Nobuaki
• Is Part Of: Hypertension in pregnancy. Volume 35:Number 2(2016)
• Page Start: 234
• Page End: 241
• Publication Date: 2016-04-02
• Subjects: Early second trimester -- gestational hypertension -- high-normal blood pressure -- preeclampsia; Hypertension in pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; 618.3261
• DOI: 10.3109/10641955.2016.1139719
• Languages: English
• ISSNs: 1064-1955

Abstract

ABSTRACT: Objective : The aim of this study was to determine the predictive value of high-normal blood pressure (HNBP) during the early second trimester for hypertensive disorders in pregnancy, including gestational hypertension (GH) and preeclampsia (PE). Methods : This was a retrospective single-center cohort study of 2143 singleton pregnant women. The association of HNBP, ranging from 130/85 to 139/89 mmHg between 14 and 19 weeks of gestation, with the development of hypertensive disorders was assessed by multivariable logistic regression analyses. Results : In a cohort of 2102 pregnant women, 93 (4.4%) pregnancies had HNBP during early second trimester. Pregnant women with HNBP more frequently developed hypertensive disorders than normotensive women (20.4% vs. 8.2%, p < 0.001). HNBP was significantly associated with the development of GH (adjusted odds ratio (aOR): 1.81; 95% confidence interval (CI): 1.16–3.25, p = 0.015) and PE (aOR: 6.05; 95% CI: 3.46–12.6, p = 0.013) after adjustment for confounders. Conclusion : HNBP during the early second trimester is an independent risk factor for both GH and PE.