Role of adiponectin on antioxidant profile: evaluation during healthy and hypertensive disorders of pregnancy. (3rd July 2016)

• Record Type: Journal Article
• Authors: Eleuterio, Níbia Mariana; Palei, Ana C. T.; Machado, Jackeline S. Rangel; Tanus-Santos, Jose E.; Cavalli, Ricardo C.; Sandrim, Valeria C.
• Is Part Of: Blood pressure. Volume 25:Number 4(2016)
• Page Start: 241
• Page End: 243
• Publication Date: 2016-07-03
• Subjects: Adipokines -- gestational hypertension -- oxidative stress -- pre-eclampsia -- pregnancy; Blood pressure -- Periodicals; Hypertension -- Periodicals; Hypertension -- Periodicals; Blood Pressure -- Periodicals; 612.14
• DOI: 10.3109/08037051.2015.1134550
• Languages: English
• ISSNs: 0803-7051

Abstract

Abstract: The study of adipokines and oxidative stress has aided in understanding pre-eclampsia physiopathology. Therefore, our group aimed to evaluate the correlation between the adipokines (adiponectin and leptin) and the oxidative stress marker malondialdehyde–thiobarbituric acid reactive substances (MDA-TBARS) and antioxidant activity of plasma [ferric reducing ability of plasma (FRAP)] in healthy pregnant women and patients with gestational hypertension and pre-eclampsia. We found a significant negative correlation between MDA-TBARS and adiponectin ( r = –0.40, p = 0.0042), suggesting a relationship between antioxidant levels and this adipokine in healthy pregnancies which is altered in patients with gestational hypertension or pre-eclampsia.