Alcohol-triggered signs of migraine: An animal model. (2nd January 2016)

• Record Type: Journal Article
• Authors: Alabwah, Yaqoub; Ji, Yadong; Seminowicz, David A.; Quiton, Raimi L.; Masri, Radi
• Is Part Of: Somatosensory & motor research. Volume 33:Number 1(2016)
• Page Start: 35
• Page End: 41
• Publication Date: 2016-01-02
• Subjects: Migraine -- headache -- trigeminal; Skin -- Innervation -- Periodicals; Somesthesia -- Periodicals; Perceptual-motor processes -- Periodicals; 573.85
• DOI: 10.3109/08990220.2016.1163258
• Languages: English
• ISSNs: 0899-0220

Abstract

Abstract: We describe an animal model where characteristics of migraine can be triggered by alcohol administration. In rats chronically implanted with a cannula overlying the transverse sinus, we applied potassium chloride (KCl) (or saline) to the meninges to sensitize trigeminovascular afferents. We assessed effects of repeated KCl application on animal behavior using conditioned place avoidance paradigm. In KCl-treated rats we discovered that alcohol injections (0.2 mg/kg), but not saline, resulted in the development of extracephalic allodynia and signs of ongoing pain.