Characteristics of audiogram configuration in multiple-system atrophy C and cortical cerebellar atrophy. (3rd March 2016)

• Record Type: Journal Article
• Authors: Omichi, Ryotaro; Maeda, Yukihide; Sugaya, Akiko; Kataoka, Yuko; Kariya, Shin; Nagayasu, Rie; Nakagawa, Atsuko; Yamashita, Toru; Abe, Koji; Nishizaki, Kazunori
• Is Part Of: Acta oto-laryngologica. Volume 136:Number 3(2016)
• Page Start: 266
• Page End: 270
• Publication Date: 2016-03-03
• Subjects: Audiogram configuration -- sensorineural hearing loss -- low-tone hearing loss -- spinocerebellar degeneration -- multiple-system atrophy C -- cortical cerebellar atrophy; Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.3109/00016489.2015.1104722
• Languages: English
• ISSNs: 0001-6489

Abstract

Abstract: Conclusion : The prevalence of low-tone hearing loss (LTHL) is significantly high in spinocerebellar degeneration (SCD) with cerebellar predominance, including multiple-system atrophy C (MSA-C) and cortical cerebellar atrophy (CCA). Objective : This study aimed to test the hypothesis that SCD with cerebellar predominance, MSA-C and CCA may cause auditory symptoms. Methods : The shape and threshold of pure-tone audiograms were evaluated for MSA-C ( n = 47; mean (± SD) age, 61.6 ± 8.9 years), CCA ( n = 16; 62.8 ± 9.5 years), and age-matched controls ( n = 169; 62.5 ± 10.7 years). To differentiate specific hearing loss for MSA-C and CCA from presbycusis, the shape of audiograms was examined based on previously established audiological criteria. Results : When audiogram shape was defined according to audiological criteria, the odds ratio for LTHL in SCD compared to controls was 2.492 (95% confidence interval (CI) = 1.208–5.139; p < 0.05, Pearson's Chi-square test) in MSA-C and 2.194 (95% CI = 0.709–6.795) in CCA. When the selection of audiogram shape according to these criteria was verified by three certified audiologists, odds ratios for LTHL in MSA-C and CCA were 3.243 (95% CI = 1.320–7.969) and 3.692 (95% CI = 1.052–12.957), respectively, significantly higher than in controls.