Effects of erdosteine on alpha amanitin-induced hepatotoxicity in mice. (2nd January 2016)

• Record Type: Journal Article
• Authors: Kaya, Ertugrul; Yilmaz, Ismail; Admis, Ozlem; Oktay, Murat; Bayram, Recep; Bakirci, Sinan; Yaykasli, Kursat Oguz; Kandis, Hayati; Saritas, Ayhan; Katirci, Yavuz; Colakoglu, Serdar
• Is Part Of: Toxin reviews. Volume 35:Number 1/2(2016)
• Page Start: 4
• Page End: 9
• Publication Date: 2016-01-02
• Subjects: Amanitin -- hepatotoxicity -- erdosteine -- silibinin -- hepatoprotection; Toxicology -- Periodicals; Toxins -- Periodicals; 615.905
• DOI: 10.1080/15569543.2016.1178146
• Languages: English
• ISSNs: 1556-9543

Abstract

Abstract: The aim of this study was to investigate beneficial effects of erdosteine in the alpha amanitine-induced hepatotoxicity in mice. Three hours after giving alpha amanitin (0.5 mg/kg, i.p.) to the mice, they were administered silibinin (50 mg/kg/d, i.p.) or erdosteine (100 mg/kg/d, oral) therapies once a day for 3 d. A histopathological examination of their liver tissues was carried out 24 h after the last treatment; transaminase levels, blood urea nitrogen, urea, and creatinine were analyzed in serum. Erdosteine showed a beneficial effect by significantly improving the functional parameters particularly in alpha amanitin-induced hepatotoxicity and partially in renal toxicity. In the histopathological evaluation, the toxicity that was generated with alpha amanitin was significantly reduced by erdosteine, showing a possible hepatoprotective effect.