The diffusive way out: Herpesviruses remodel the host nucleus, enabling capsids to access the inner nuclear membrane. (1st March 2016)

• Record Type: Journal Article
• Authors: Bosse, Jens B.; Enquist, Lynn W.
• Is Part Of: Nucleus. Volume 7:Number 1(2016)
• Page Start: 13
• Page End: 19
• Publication Date: 2016-03-01
• Subjects: capsid -- egress -- herpes -- nucleus -- nuclear actin -- ring-sheet; Cell nuclei -- Periodicals; Biology -- Periodicals; Biology; Cell nuclei; Periodicals; 571.6605
• DOI: 10.1080/19491034.2016.1149665
• Languages: English
• ISSNs: 1949-1034

Abstract

ABSTRACT: Herpesviruses are large DNA viruses that utilize the host nucleus for genome replication as well as capsid assembly. After maturation, these 125 nm large capsid assemblies must cross the nucleoplasm to engage the nuclear envelope and bud into the cytoplasm. Here we summarize our recent findings how this motility is facilitated. We suggest that herpesvirus induced nuclear remodeling allows capsids to move by diffusion in the nucleus and not by motor-dependent transport.