Flow-assisted basophil activation tests in immediate drug hypersensitivity: two decades of Antwerp experience. Issue 1 (2nd January 2016)

• Record Type: Journal Article
• Authors: Mangodt, E. A.; Van Gasse, A. L.; Bastiaensen, A.; Decuyper, I. I.; Uyttebroek, A.; Faber, M.; Sabato, V.; Bridts, C. H.; Hagendorens, M. M.; De Clerck, L. S.; Ebo, D. G.
• Is Part Of: Acta clinica belgica. Volume 71:Issue 1(2016)
• Page Start: 19
• Page End: 25
• Publication Date: 2016-01-02
• Subjects: Allergy -- Antibiotics -- Basophil activation test (BAT), drug -- CD63 -- CD203c -- Curares -- HistaFlow -- Immediate drug hypersensitivity reaction (IDHR) -- Opiates; Clinical medicine -- Periodicals; Diagnosis, Laboratory -- Periodicals; 616.005
• DOI: 10.1080/17843286.2015.1122871
• Languages: English
• ISSNs: 1784-3286

Abstract

Abstract : The last two decades have witnessed that flow-assisted analysis of in vitro- activated basophils can constitute a valuable adjunct in the in vitro diagnostic approach of immediate drug hypersensitivity reactions (IDHR). This article summarises the current experience with the basophil activation test in the diagnosis of IDHR, with particular focus on allergy to curarising neuromuscular blocking agents, antibiotics (β-lactams and fluoroquinolones), iodinated radiocontrast media and opiates.