Remission With Donor Lymphocyte Infusion in a Child With Marrow Relapse After Haploidentical Stem Cell Transplantation for Relapsed Stage 4 Neuroblastoma. Issue 8 (21st April 2016)

• Record Type: Journal Article
• Authors: Liu, A. P. Y.; Leung, R. Y. Y.; Cheuk, K. L.; Lee, P. P. W.; Chiang, A. K. S.; Ha, S. Y.; Chan, G. C. F.
• Is Part Of: Pediatric blood & cancer. Volume 63:Issue 8(2016)
• Page Start: 1477
• Page End: 1479
• Publication Date: 2016-04-21
• Subjects: donor lymphocyte infusion -- graft versus tumor effect -- haploidentical hematopoietic stem cell transplantation -- neuroblastoma; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.26023
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract : A 7‐year‐old male with Stage 4 neuroblastoma was treated with chemotherapy and autologous hematopoietic stem cell transplantation (HSCT), resulting in partial response with residual bone and marrow disease. He proceeded to haploidentical‐HSCT with his mother as donor and achieved remission. The patient developed marrow relapse 2 years after haploidentical‐HSCT with cytopenia and dropping donor chimerism. Donor lymphocyte infusion (DLI) using mother's whole blood was given resulting in clearance of marrow disease, resolution of cytopenia, and full donor chimerism. This is the first report of successful treatment for neuroblastoma relapse after haploidentical‐HSCT using DLI alone, supporting the role of adoptive cell therapy post‐HSCT in neuroblastoma.