Low Frequency of Programmed Death Ligand 1 Expression in Pediatric Cancers. Issue 8 (2nd May 2016)

• Record Type: Journal Article
• Authors: Aoki, Takahiro; Hino, Moeko; Koh, Katsuyoshi; Kyushiki, Masashi; Kishimoto, Hiroshi; Arakawa, Yuki; Hanada, Ryoji; Kawashima, Hiroshi; Kurihara, Jun; Shimojo, Naoki; Motohashi, Shinichiro
• Is Part Of: Pediatric blood & cancer. Volume 63:Issue 8(2016)
• Page Start: 1461
• Page End: 1464
• Publication Date: 2016-05-02
• Subjects: PD‐1/PD‐L1 blockade -- pediatric cancer -- tumor‐infiltrating lymphocyte; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.26018
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract : Programmed death 1 (PD‐1)/programmed death ligand 1 (PD‐L1) pathway blockade has become a promising therapeutic target in adult cancers. We evaluated PD‐L1 expression and tumor‐infiltrating CD8 + T cells in formalin‐fixed, paraffin‐embedded tumor specimens from 53 untreated pediatric patients with eight cancer types: neuroblastoma, extracranial malignant germ cell tumor, hepatoblastoma, germinoma, medulloblastoma, renal tumor, rhabdomyosarcoma, and atypical teratoid/rhabdoid tumor. One rhabdomyosarcoma with the shortest survival exhibited membranous PD‐L1 expression and germinoma contained abundant tumor‐infiltrating CD8 + T cells and PD‐L1‐positive macrophages. The PD‐1/PD‐L1 pathway tended to be inactive in pediatric cancers.