Patterns of Failure for Pediatric Glioblastoma Multiforme Following Radiation Therapy. Issue 8 (29th April 2016)

• Record Type: Journal Article
• Authors: Shabason, Jacob E.; Sutton, David; Kenton, Owen; Guttmann, David M.; Lustig, Robert A.; Hill‐Kayser, Christine
• Is Part Of: Pediatric blood & cancer. Volume 63:Issue 8(2016)
• Page Start: 1465
• Page End: 1467
• Publication Date: 2016-04-29
• Subjects: patterns of failure -- pediatric glioblastoma -- radiation therapy; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.26031
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract : Despite aggressive multimodal therapy for pediatric glioblastoma multiforme (GBM), patient survival remains poor. This retrospective review of patients with GBM aims to evaluate the patterns of failure after radiation therapy (RT). The study included 14 pediatric patients treated with RT at the Children's Hospital of Philadelphia from 2007 to 2015. With a median follow‐up of 16.9 months, 13 (92.9%) developed recurrent disease. Of recurrences, nine (69.2%) were in‐field, three (23.1%) were marginal, and one (7.7%) was distant. The majority of patients treated with adjuvant radiation failed in the region of high‐dose RT, indicating the need for improvements in local therapy.