Overexpression of collagen XIII in extraocular fat affected by active thyroid-associated ophthalmopathy: A crucial piece of the puzzle?. (3rd July 2016)

• Record Type: Journal Article
• Authors: Morris, Olivia Claire; Schebitz Walter, Kirsten; Telemo, Esbjörn; Hintschich, Christoph
• Is Part Of: Orbit. Volume 35:Number 4(2016)
• Page Start: 227
• Page End: 232
• Publication Date: 2016-07-03
• Subjects: Thyroid-associated ophthalmopathy -- thyroid eye disease -- collagen XIII -- COL13A1 -- extraocular fat; Eye-sockets -- Surgery -- Periodicals; Eye-sockets -- Diseases -- Periodicals; Orbit -- surgery -- Periodicals; Orbital Diseases -- Periodicals; 617.7
• DOI: 10.1080/01676830.2016.1176055
• Languages: English
• ISSNs: 0167-6830

Abstract

ABSTRACT: Thyroid-associated ophthalmopathy (TAO) causes irreversible increase in extraocular fat volume that contributes to the risk of exophthalmos and compressive optic neuropathy. Collagen XIII is implicated in uncontrolled cell growth in some tumours, but we are not aware of any studies of collagen XIII in TAO-affected solid tissue to date. We conducted immunohistochemical staining for collagen XIII alpha 1 (COL13A1), present in both the transmembrane and cleaved forms of collagen XIII, in consecutive prospectively collected human extraocular tissue specimens from patients with TAO and controls. We identified overexpression of collagen XIII in active TAO-affected fat. We discuss how species and cell-type specific responses of collagen XIII to stressors may help explain the different phenotypes of TAO.