A multicenter phase II study of concurrent chemoradiotherapy with cisplatin and oral S-1, followed by surgery for locally advanced non-small-cell lung cancer. (2016)

• Record Type: Journal Article
• Authors: Tsuchiya, Tomoshi; Nakamura, Yoichi; Hayashi, Nobuyuki; Matsumoto, Keitaro; Miyazaki, Takuro; Nakatomi, Katsumi; Fukuda, Minoru; Yamasaki, Takuya; Shimada, Midori; Sano, Isao; Taniguchi, Hirokazu; Tabata, Kazuhiro; Fukuoka, Junya; Tagawa, Tsutomu; Yamasaki, Naoya; Nagayasu, Takeshi
• Is Part Of: Cancer treatment communications. Volume 7(2016)
• Page Start: 11
• Page End: 16
• Publication Date: 2016
• Subjects: Phase II study -- Induction chemoradiotherapy -- Cisplatin -- S-1 -- Surgery -- Non-small-cell lung cancer; Cancer -- Periodicals; Cancer -- Treatment -- Periodicals; 616.994005
• DOI: 10.1016/j.ctrc.2016.02.010
• Languages: English
• ISSNs: 2213-0896

Abstract

Abstract: Purpose: This study was designed to evaluate the feasibility of concurrent induction chemoradiotherapy (CRT) using S-1, an oral fluoropyrimidine derivative, plus cisplatin followed by surgery in locally advanced non-small cell lung cancer (NSCLC). Patients and methods: We defined locally advanced NSCLC as pathologically proven chest wall invasion or hilar and/or mediastinal lymph node metastases by endobronchial ultrasound-guided transbronchial needle aspiration. Twenty-three patients were enrolled in this study from May 2011 to April 2014. The patients received S-1 40 mg/m 2 orally twice daily on days 1 through 14 and 29 through 42, and cisplatin 60 mg/m 2 was injected intravenously on days 8 and 36. The patients also underwent radiotherapy and received a total dose of 40 Gy in 20 fractions beginning on day 1. Surgical resection was performed from 4 to 6 weeks after completion of the induction treatment. Results: Of the 23 eligible patients, 18 had stage IIIA and 5 had stage IIB NSCLC. Twenty patients (87.0%) completed induction CRT and underwent surgical resection. Representative grade 3 adverse reactions were neutropenia (21.7%) and leukocytopenia (8.7%); no grade 4 adverse reactions were observed. Radiologically, 7 (30.4%) of the 23 patients achieved partial response and were therefore radiologically downstaged. Twenty patients were curatively resected. Six (26.1%) complete responses were identified and 12 cases (52.2%) were histopathologically downstaged by induction CRT. Conclusion: Concurrent induction CRT using S-1 plus cisplatin is a feasible and promising new treatment modality for locally advanced NSCLC. Evaluation of histopathological downstaging revealed sufficient anti-cancer effects for preoperative treatment. MicroAbstract: Because chemoradiotherapy (CRT) using cisplatin and S-1, an oral fluoropyrimidine, is effective for unresectable non-small cell lung cancer, the feasibility of this therapy in a neoadjuvant setting was evaluated in a multicenter phase II study. Toxicities were very mild and 87.0% of the 23 patients completed induction CRT. This protocol seems feasible and is considered an option among preoperative therapies.