Evaluation of sentinel lymph node biopsy after previous breast surgery for breast cancer: GATA study. (August 2016)

• Record Type: Journal Article
• Authors: Renaudeau, C.; Lefebvre-Lacoeuille, C.; Campion, L.; Dravet, F.; Descamps, P.; Ferron, G.; Houvenaeghel, G.; Giard, S.; Tunon de Lara, C.; Dupré, P.F.; Fritel, X.; Ngô, C.; Verhaeghe, J.L.; Faure, C.; Mezzadri, M.; Damey, C.; Classe, J.M.
• Is Part Of: Breast. Volume 28(2016)
• Page Start: 54
• Page End: 59
• Publication Date: 2016-08
• Subjects: Invasive breast carcinoma -- Sentinel lymph node biopsy -- Previous breast surgery -- Surgical biopsy; Breast -- Diseases -- Periodicals; Breast -- Tumors -- Periodicals; Breast -- Periodicals; Electronic journals; Periodicals; 616
• DOI: 10.1016/j.breast.2016.04.006
• Languages: English
• ISSNs: 0960-9776

Abstract

Abstract: Aim: Sentinel lymph node (SLN) biopsy was recently recommended after prior breast tumour surgery and lymphadenectomy is not the gold standard anymore for nodal staging after a lesion's removal. The purpose of our study was to evaluate the good practices of use of SLN biopsy in this context. Patients and methods: From 2006 to 2012, 138 patients having undergone a surgical biopsy without prior diagnosis of an invasive carcinoma with a definitive histological analysis in favour of this diagnosis were included in a prospective observational multicentric study. Each patient had a nodal staging following SLN biopsy with subsequent systematic lymphadenectomy. Results: The detection rate of SLN was 85.5%. The average number of SLNs found was 1.9. The relative detection failure risk rate was multiplied by 4 in the event of an interval of less than 36 days between the SLN biopsy and the previous breast surgery, and by 9 in the event of using a single-tracer detection method. The false negative rate was 6.25%. The prevalence of metastatic axillary node involvement was 11.6%. In 69% of cases only the SLN was metastatic. The post-operative seroma rate was 19.5%. Conclusion: Previous conservative breast tumour surgery does not affect the accuracy of the SLN biopsy. A sufficient interval of greater than 36 days between the two operations could allow to improve the SLN detection rate, although further studies are needed to validate this statement. Clinical trial registration number: NCT00293865 . Highlights: The SLN biopsy in patients who have undergone prior breast surgery is accurate. The identification rate of sentinel lymph node was 85.5% in our study. The false negative rate of sentinel lymph node was 6.25% in our study. An interval of more than 36 days after breast surgery improves the SLN detection rate.