APG1233 is a novel hexavalent CD40 agonist acting on monocyte differentiation and macrophage-polarization and promotes increased activation of CD4+ T cells by shifting M1/M2 macrophage balance. (July 2016) - Merz, C.; Sykora, J.; Beyer, T.; Richards, D.; Fricke, H.; Gieffers, C.; Hill, O.