Long-term quality of life among localised prostate cancer survivors: QALIPRO population-based study. (August 2016)

• Record Type: Journal Article
• Authors: Woronoff, Anne-Sophie; Trétarre, Brigitte; Delafosse, Patricia; Molinié, Florence; Bara, Simona; Velten, Michel; Marrer, Emilie; Lapôtre-Ledoux, Bénédicte; Cowppli-Bony, Anne; Kerleau, Clarisse; Guizard, Anne-Valérie; Daubisse-Marliac, Laetitia; Heutte, Natacha; Mercier, Mariette; Grosclaude, Pascale; Joly, Florence
• Is Part Of: European journal of cancer. Volume 63(2016)
• Page Start: 143
• Page End: 153
• Publication Date: 2016-08
• Subjects: Quality of life -- Localised prostate cancer -- Long survivors -- Population based study; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Cancer; Tumors; Electronic journals; Periodicals; Electronic journals; 616.994
• DOI: 10.1016/j.ejca.2016.05.020
• Languages: English
• ISSNs: 0959-8049

Abstract

Abstract: Background: To evaluate quality of life (QoL) 10 years after treatments for localised prostate cancer (LPCa) patients in comparison with aged-matched healthy controls. Methods: LPCa patients diagnosed in 2001 were obtained from 11 French cancer registries. Controls were recruited among the general population and were matched to patients on age and geographic area. EORTC Quality of Life Questionnaire – Core 30 items, Expanded Prostate Cancer Index Composite, Hospital Anxiety and Depression Scale and Multidimensional Fatigue Inventory self-reported questionnaires were used to measure QoL, anxiety and fatigue. Patients were classified in three groups according to previous treatments: radical prostatectomy (RP), radiotherapy (RT) and radical prostatectomy and radiotherapy (RP+RT). The differences in QoL between patients and controls and according to treatment groups were evaluated. Results: There were 287 patients and 287 controls. There was no socio-demographic difference between patients and controls. Treatments were: RP (143), RT (78), PR+RT (33), baseline hormone therapy (49) and hormone therapy at the time of the study (34). Patients had similar levels of global QoL, anxiety, depression and fatigue as controls. They reported more urinary troubles (urinary function and incontinence) (p < 0.0001) and more sexual dysfunctions (p < 0.0001) than controls, whatever the treatment group. Worse bowel dysfunction was reported in patients treated by RT and RP+RT (p < 0.002). According to the treatments, RP groups had the worst urinary function and incontinence (p < 0.01), and reported more bowel bother when the treatment was combined with RT. Conclusions: Even though patients reported similar global QoL as control 10 years after treatment, patients reported numerous urinary and sexual dysfunctions. Patients treated with RP+RT reported cumulative sequelae of both treatments. Highlights: Ten years after treatment, patients reported similar global quality of life than controls. Nevertheless, they presented persistent urinary, bowel and sexual adverse effects. Patients treated with radical prostatectomy and radiotherapy reported cumulative sequelae of both treatments.