Palladium catalyzed C–H bond acetoxylation: isoxazolinyl as a directing group. Issue 62 (14th June 2016)

• Record Type: Journal Article
• Authors: Geng, Caiwei; Jiang, Minghui; Feng, Lifei; Jiao, Peng
• Is Part Of: RSC advances. Volume 6:Issue 62(2016)
• Page Start: 56971
• Page End: 56976
• Publication Date: 2016-06-14
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra07793e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Pd(OAc)2 -catalyzed acetoxylations of 3-aryl or 3-alkyl groups mounted on a 2-isoxazoline ring were studied. Substituent effect on reactivity and regioselectivity was examined. The acetoxylation was applied to the synthesis of useful intermediates. Abstract : Pd(OAc)2 -catalyzed acetoxylations of 3-aryl or 3-alkyl groups mounted on a 2-isoxazoline ring were studied. Ortho -selective C–H bond activation directed by an isoxazolinyl group was realized. 2-Isoxazoline rings without and with one or two alkyl substituents in the 5-position were effective directing groups. The substituent effect on reactivity and regioselectivity was examined. The acetoxylation was applied to the synthesis of useful intermediates.