CT fluoroscopy-guided closed-tip catheter placement before regional hyperthermia treatment of soft tissue sarcomas: 5-Year experience in 35 consecutive patients. (17th February 2016)

• Record Type: Journal Article
• Authors: Strobl, Frederik F.; Azam, Houman; Schwarz, Jens B.; Paprottka, Philipp M.; Geith, Tobias; Abdel-Rahman, Sultan; Zilles, Benjamin; Lindner, Lars H.; Reiser, Maximilian F.; Trumm, Christoph G.
• Is Part Of: International journal of hyperthermia. Volume 32:Number 2(2016)
• Page Start: 151
• Page End: 158
• Publication Date: 2016-02-17
• Subjects: Closed-tip catheter placement -- CT fluoroscopy -- regional hyperthermia -- soft tissue sarcoma -- thermometry; Thermotherapy -- Periodicals; 615.832
• DOI: 10.3109/02656736.2015.1107761
• Languages: English
• ISSNs: 0265-6736

Abstract

Abstract: Purpose : This study was designed to assess technical success and complications in patients with high-risk soft tissue sarcomas undergoing CT fluoroscopy-guided closed-tip catheter placement before treatment with combined chemotherapy and regional hyperthermia. Materials and methods : This retrospective study comprised all patients referred for insertion of closed-tip catheters for the introduction of thermometry probes before regional hyperthermia treatment at a single university centre from 2010 to 2015. Catheter placements were performed under local anaesthesia and intermittent CT fluoroscopy guidance. Technical success, complication rate, duration of catheter insertion and dose–length product (DLP) were analysed. Technical success was defined as intratumoural catheter placement suitable for subsequent thermometry. Results : A total of 35 procedures were performed on 35 patients (22 men, 13 women). In 34 out of 35 interventions catheters were inserted successfully; in one patient catheter placement was not feasible. No intra-interventional complications occurred. In six patients post-interventional complications were observed – two major (one abscess formation and one severe catheter dislocation) and four minor complications. Technical failure was observed in 11.4% of patients, especially catheter kinking. A total of 55 catheters were placed, with a mean number of 1.7 ± 0.7 per patient. Mean total DLP was 723.2 ± 355.9 mGy*cm. Conclusion : CT fluoroscopy-guided closed-tip catheter placement into high-risk soft tissue sarcomas was characterised by high technical success and relatively low complication rate. While major complications were rarely observed, catheter-kinking preventing successful thermometry represented the most frequent technical failure.