Promotion of 1, 3-dipolar cycloaddition between azides and β-enaminones by deep eutectic solvents. (16th May 2016)

• Record Type: Journal Article
• Authors: Martins, Marcos Antonio Pinto; Paveglio, Guilherme Caneppele; Rodrigues, Leticia Valvassori; Frizzo, Clarissa Piccinin; Zanatta, Nilo; Bonacorso, Helio Gauze
• Is Part Of: New journal of chemistry. Volume 40:Number 7(2016:Jul.)
• Page Start: 5989
• Page End: 5992
• Publication Date: 2016-05-16
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c5nj03654b
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : The metal-free, high selectivity and efficient synthesis of 4-acyl triazoles in a DES (ChCl:ethylene glycol) is reported. Abstract : A simple procedure to obtain 4-acyl-1-substituted-1, 2, 3-triazoles, using a deep eutectic solvent (DES), ChCl and ethylene glycol at a 1 : 2 ratio, as the reaction medium is described. The products were obtained in high selectivity and good yields (70–84%). The advantages of the method include easy work-up, metal-free conditions, inexpensiveness, and the ability to be used four times without a loss in yield.