Cu(ii)-catalyzed C6-selective C–H thiolation of 2-pyridones using air as the oxidant. Issue 62 (15th June 2016) - Peng, Panfeng
Abstract : Cu(II)-catalyzed C6-selective C–H thiolation of 2-pyridones with aryl and alkyl disulfides to provide functional thioethers has been achieved. Abstract : The Cu(ii )-catalyzed and chelate-directed C6-selective C–H thiolation of 2-pyridones with disulfides was developed to provide aryl and alkyl thioethers. This transformation uses a catalytic amount of Cu(OAc)2 and molecular oxygen in air as an oxidant, no cocatalysts or metallic oxidants are required. The reaction accommodated both electronic and steric factors at the C3–C5 positions of 2-pyridones, which is efficient for the C6 thiolation of a broad range of 2-pyridones with up to 93% yield.