A synthesized butyrolactone derivative in combination with chloroquine can inhibit cancer cell growth and lysosome vacuolation induced by chloroquine in A549 lung cancer cells. Issue 59 (3rd June 2016) - Chen, Xin-Peng
Abstract : 3BDO in combination with chloroquine could elevate the Na +, K + -ATPase activity and decrease the expression of competing endogenous non-coding RNA TGFB2-OT1 . Therefore, ​ the combination inhibited the cells growth and lysosomal vacuolation induced by CQ. Abstract : 3BDO in combination with chloroquine could elevate the Na +, K + -ATPase activity and decrease the expression of long non-coding RNA TGFB2-OT1 . Therefore, the combination inhibited the cell growth and lysosomal vacuolation.