One-pot relay catalysis: divergent synthesis of furo[3, 4-b]indoles and cyclopenta[b]indoles from 3-(2-aminophenyl)-1, 4-enynols. Issue 24 (3rd March 2016)

• Record Type: Journal Article
• Authors: Manisha, ; Dhiman, Seema; Mathew, Jopaul; Ramasastry, S. S. V.
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 24(2016)
• Page Start: 5563
• Page End: 5568
• Publication Date: 2016-03-03
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob00319b
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Described herein a divergent strategy for the synthesis of furo[3, 4- b ]indoles via a sequential Ag(i )/Bi(iii )/Pd(ii ) catalysis and cyclopenta[ b ]indoles via a one-pot Ag(i )/Brønsted acid relay catalysis, starting from the easily accessible 3-(2 aminophenyl)-4-pentenyn-3-ols. Abstract : Described herein is an efficient divergent strategy for the synthesis of furo[3, 4- b ]indoles via a sequential Ag(i )/Bi(iii )/Pd(ii ) catalysis and cyclopenta[ b ]indoles via a one-pot Ag(i )/Brønsted acid relay catalysis from 3-(2-aminophenyl)-4-pentenyn-3-ols, accessible in three simple steps from 2-aminobenzaldehydes.