An efficient base-catalyzed double addition of H-phosphine oxides to alkynes. Issue 30 (27th July 2016)

• Record Type: Journal Article
• Authors: Yoshimura, Aya; Saga, Yuta; Sato, Yuki; Ogawa, Akiya; Chen, Tieqiao; Han, Li-Biao
• Is Part Of: Tetrahedron letters. Volume 57:Issue 30(2016)
• Page Start: 3382
• Page End: 3384
• Publication Date: 2016-07-27
• Subjects: Base-catalysis -- Double addition -- Alkynes -- H-phosphine oxides -- Transition metal-free; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.06.079
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: An efficient base-catalyzed (transition metal-free) double addition of H-phosphine oxides to alkynes is developed. In the presence of a catalytic amount of t -BuOLi, various 1, 2-bisphosphoryl compounds were produced in high yields. This method provides an easy direct way to prepare bisphosphine oxides that are of high importance in organic synthesis. Abstract: An efficient base-catalyzed double addition of H-phosphine oxides to alkynes is developed. In the presence of a catalytic amount of a base, the addition of various H-phosphine oxides to both aromatic and aliphatic alkynes took place efficiently to produce the corresponding bisphosphoryl compounds in excellent yields. This method provides an easy direct way to prepare bisphosphine oxides that are of high importance in organic synthesis.