Sodium chlorate as a viable substoichiometric oxidant for cobalt-catalyzed oxidative annulation of aryl sulfonamides with alkynes. Issue 30 (27th July 2016)

• Record Type: Journal Article
• Authors: Ran, You; Yang, Yudong; Zhang, Luoqiang
• Is Part Of: Tetrahedron letters. Volume 57:Issue 30(2016)
• Page Start: 3322
• Page End: 3325
• Publication Date: 2016-07-27
• Subjects: Cobalt catalysis -- Sultam -- C–H activation -- Oxidative annulation; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.06.059
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Synthesis of sultams through cobalt-catalyzed oxidative annulation. NaClO3 proved to be a versatile oxidant in C–H activation reaction. Moderate to excellent yields with excellent regioselectivity could be obtained. A broad scope of functional groups could be tolerant. Abstract: In this work, NaClO3 is demonstrated for the first time as an efficient and versatile oxidant in the catalytic C–H activation reaction. By using sodium chlorate as the oxidant, a highly regioselective cobalt-catalyzed oxidative annulation of aryl sulfonamides with alkynes has been developed and can be extended to the annulation of benzamide.