How we manage patients with heparin induced thrombocytopenia. (21st April 2016)

• Record Type: Journal Article
• Authors: Scully, Marie; Gates, Carolyn; Neave, Lucy
• Is Part Of: British journal of haematology. Volume 174:Number 1(2016)
• Page Start: 9
• Page End: 15
• Publication Date: 2016-04-21
• Subjects: heparin induced thrombocytopenia -- thrombosis -- non heparin anticoagulants -- direct acting oral anticoagulants; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.14102
• Languages: English
• ISSNs: 0007-1048

Abstract

Summary: Heparin induced thrombocytopenia (HIT) remains a rare, but significant, condition related to mortality and morbidity. The incidence has decreased with reduced use of unfractionated heparin, with the exception of cardiac surgery. Due to the high risk of thrombosis, a switch to a non‐heparin anticoagulant is required, until platelet counts normalize. Within the acute setting, argatroban, fondaparinux and direct acting oral anticoagulants (DOACS) are therapeutic options. In patients with HIT‐associated thrombosis or who require long‐term anticoagulation, warfarin remains the preference, but DOACs are attractive alternatives.