Purification of Ginkgo biloba Extract by Antisolvent Recrystallization. Issue 7 (16th June 2016)

• Record Type: Journal Article
• Authors: Zu, Yuan Gang; Wang, Lingling; Zhao, Xiuhua; Li, Yuanyuan; Wu, Weiwei; Zu, Chang; Huang, Yannian; Wu, Mingfang; Feng, Ziqi
• Other Names: Kim Kwang‐Joo sponsoringEditor.
• Is Part Of: Chemical engineering & technology. Volume 39:Issue 7(2016:Jul.)
• Page Start: 1301
• Page End: 1308
• Publication Date: 2016-06-16
• Subjects: Antisolvent recrystallization -- Flavonoids -- Ginkgo biloba extract; Chemical engineering -- Periodicals; Chemical processes -- Periodicals; 660.05
• DOI: 10.1002/ceat.201500691
• Languages: English
• ISSNs: 0930-7516

Abstract

Abstract: The content of flavonoids in Gingko biloba extract (GBE) could be increased by antisolvent recrystallization (ASR) using ethanol as solvent and hexane as antisolvent. By means of the single‐factor method, the effect of main factors on the content of flavonoids in purified GBE was investigated. Under optimal conditions, the content of flavonoids and ginkgo terpene lactones in purified GBE could be significantly enhanced. In addition, the content of total ginkgolic acid in purified GBE was reduced. The morphologies of raw and purified GBE were characterized by scanning electron microscopy. It was found that the particle size of purified GBE was much smaller than that of raw GBE. At the same time, the saturated solubility could be improved by more than four times. Abstract : The content of flavonoids and ginkgo terpene lactones in Gingko biloba extract could be significantly improved by antisolvent recrystallization using ethanol as solvent and n ‐hexane as antisolvent. The content of total ginkgolic acid could be reduced. The impact of main factors on the content of flavonoids in the purified extract was investigated by means of the single‐factor method.