Carbonic anhydrase IX deposits are associated with increased ascending aortic dilatation. (3rd May 2016)

• Record Type: Journal Article
• Authors: Niinimaki, Eetu; Muola, Petteri; Parkkila, Seppo; Kholová, Ivana; Haapasalo, Hannu; Pastorekova, Silvia; Pastorek, Jaromir; Paavonen, Timo; Mennander, Ari
• Is Part Of: Scandinavian cardiovascular journal. Volume 50:Number 3(2016:Jun.)
• Page Start: 162
• Page End: 166
• Publication Date: 2016-05-03
• Subjects: Ascending aortic dilatation -- CA IX -- inflammation; Cardiovascular system -- Diseases -- Periodicals; 617.41
• DOI: 10.3109/14017431.2016.1158416
• Languages: English
• ISSNs: 1401-7431

Abstract

Abstract: Objectives . Carbonic anhydrase IX (CA IX) expression is induced by local hypoxia. We studied whether CA IX deposits associate with ascending aortic dilatation. Design . Aortic wall histology, CA IX expression, presence of leukocytes, plasma cells, macrophages, endothelial cells, smooth muscle cells, cell proliferation, elastin and collagen were studied in histological specimens collected from 30 patients who underwent surgery for ascending aorta. The samples were grouped according to presence of CA IX deposits. Results . Twenty out of 30 patients had CA IX-positive deposits within the adventitia, whereas 10 specimens remained negative. Adventitial inflammation was increased in CA IX-positive samples as compared with CA IX-negative ones (p < 0.01). The mean diameter of the ascending aorta at the sinotubular junction increased significantly in patients with CA IX-positive staining as compared with CA IX-negative cases (63 ± 3 vs 53 ± 2 mm, p < 0.02). Receiver operating characteristic curve analysis confirmed the association of CA IX positivity with increased ascending aortic dilatation (AUC 0.766; S.E. 0.090; p = 0.020; 95% C.I. 0.590–0.941). Conclusions . Positive CA IX staining in certain aortic specimens suggests that increased CA activity may contribute to ascending aortic dilatation.