Immunoglobulin-induced hemolysis, splenomegaly and inflammation in patients with antibody deficiencies. (2nd July 2016)

• Record Type: Journal Article
• Authors: Pulvirenti, Federica; Granata, Guido; Girelli, Gabriella; Quinti, Isabella
• Is Part Of: Expert review of clinical immunology. Volume 12:Number 7(2016)
• Page Start: 725
• Page End: 731
• Publication Date: 2016-07-02
• Subjects: Primary Antibody Defects -- Hemolysis -- Immunoglobulin replacement therapy -- Immunoglobulin-Induced Hemolysis -- Common Variable Immune Deficiency -- Splenomegaly -- Inflammation; Clinical immunology -- Periodicals; 616.079
• DOI: 10.1586/1744666X.2016.1151787
• Languages: English
• ISSNs: 1744-666X

Abstract

ABSTRACT: IgG replacement for primary antibody deficiencies is a safe treatment administered to prevent recurrent infections and reduce mortality. Recently, several reports described acute hemolytic episodes following IgG administration due to a passive transfer of blood group alloantibodies, including anti-A, anti-B, as well as anti-Rh antibodies. Here, we reviewed and discussed the consequences of passively transferred RBCs antibodies. The chronic passive transfer of alloantibodies might also cause a subclinical condition due to a compensated extravascular chronic hemolysis with poorly understood consequences. This phenomenon might possibly represent an unrecognized cause of splenomegaly and might contribute to inflammation in patients with primary antibody deficiencies.