(−)-Epicatechin in vitro ameliorates erythrocyte protein carbonyl content in hypertensive patients: comparison with L-ascorbic acid. (26th May 2016)

• Record Type: Journal Article
• Authors: Kumar, Navneet; Maurya, Pawan Kumar; Kant, Ruchi; Rizvi, Syed Ibrahim
• Is Part Of: Archives of physiology and biochemistry. Volume 122:Number 3(2016)
• Page Start: 155
• Page End: 160
• Publication Date: 2016-05-26
• Subjects: Carbonyl group -- epicatechin -- erythrocyte -- hypertension -- oxidative stress; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.3109/13813455.2016.1159699
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: Context : Oxidative stress plays a key role in the patho-physiology of hypertension. (−)-Epicatechin has many important biological properties. Objective : The present study was undertaken to evaluate effect of (−)-epicatechin on protein carbonyl content in gender-based hypertensive patients and normal subjects. Methods : The study was carried out on 83 normal (male: 42; female: 41) and 62 hypertensive subjects (male: 32; female: 30). In vitro effect on (−)-epicatechin and L-ascorbic acid was estimated on protein carbonyl content. Results : Result showed a significant ( p < 0.001) increase in protein carbonyl content in hypertensive patients but no gender-based difference was observed. (−)-epicatechin shows significant ( p < 0.001) dose-dependent effect as compared to L-ascorbic acid, which is manifested as decrease in protein carbonyl content. Conclusion : We hypothesizes that a higher intake of (−)-epicatechin may provide protection against hypertension in males and females.