Fuchs' Uveitis Syndrome: No Longer a Syndrome?. (3rd May 2016)

• Record Type: Journal Article
• Authors: Kreps, Elke Olivia; Derveaux, Thierry; De Keyser, Filip; Kestelyn, Philippe
• Is Part Of: Ocular immunology and inflammation. Volume 24:Number 3(2016)
• Page Start: 348
• Page End: 357
• Publication Date: 2016-05-03
• Subjects: Cytokines -- etiology -- Fuchs' uveitis syndrome -- immunology -- rubella virus; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.3109/09273948.2015.1005239
• Languages: English
• ISSNs: 0927-3948

Abstract

Abstract: Purpose : Rubella virus (RV) has a central role in the etiopathogenesis of Fuchs' uveitis syndrome (FUS). We aim to offer new insights by comprehensive analysis of recent laboratory and epidemiologic data. Methods : We conducted a literature search for laboratory data and papers on etiopathogenesis. Results : Aqueous humour samples of FUS patients show immunoreactivity to RV, in a specific and sensitive manner. Identification of RV genome confirm intraocular infection in a subset of FUS patients. Epidemiologic findings further support causality. The clinical spectrum of RV-associated uveitis is similar but not identical to FUS. FUS eyes exhibit a predominance of CD8 + T cells, high IFN-? and IL-10 levels. Conclusions : RV is the leading cause of FUS. Cytokine-based findings mirror a viral etiology and chronic low-grade inflammation. RV-associated FUS represents a common pathway of intraocular RV inoculation after congenital or acquired infection. Other causes, including HSV and CMV, may lead to FUS.