Spectral-domain Optical Coherence Tomography Patterns in Intraocular Lymphoma. (3rd May 2016)

• Record Type: Journal Article
• Authors: Keino, Hiroshi; Okada, Annabelle A.; Watanabe, Takayo; Echizen, Nariaki; Inoue, Makoto; Takayama, Nobuyuki; Nagane, Motoo
• Is Part Of: Ocular immunology and inflammation. Volume 24:Number 3(2016)
• Page Start: 268
• Page End: 273
• Publication Date: 2016-05-03
• Subjects: Intraocular lymphoma -- spectral domain optical coherence tomography; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.3109/09273948.2014.1002568
• Languages: English
• ISSNs: 0927-3948

Abstract

Abstract: Purpose : To examine spectral-domain optical coherence tomography (SD-OCT) patterns in intraocular lymphoma (IOL). Methods : Records of 13 patients (21 eyes) with IOL were retrospectively reviewed. SD-OCT was evaluated at initial visit and during follow-up. Results : SD-OCT images at initial visit demonstrated disruption of the ellipsoid zone (8 eyes, 38.1%) and hyperreflective nodules at the retinal pigment epithelium (RPE) level (5 eyes, 23.8%). During follow-up, disruption of the ellipsoid zone (10 eyes, 47.6%) and hyperreflective nodules at the RPE level (7 eyes, 33.3%) were noted. In 5 eyes showing hyperreflective nodules at the RPE level, the hyperreflective nodules were reduced after treatment with intravitreal methotrexate. Conclusions : Hyperreflective nodules in the outer retina and disruption of the ellipsoid zone were observed in nearly one-half of patients with IOL over time. SD-OCT may allow for early detection of small macular abnormalities and aid in monitoring of treatment efficacy in this disease.