Does the Presence of Endometriosis Affect Prognosis of Ovarian Cancer?. (15th March 2016)

• Record Type: Journal Article
• Authors: Dinkelspiel, Helen E; Matrai, Cathleen; Pauk, Sara; Pierre-Louis, Alain; Chiu, Ya-Lin; Gupta, Divya; Caputo, Thomas; Ellenson, Lora Hedrick; Holcomb, Kevin
• Is Part Of: Cancer investigation. Volume 34:Number 3(2016)
• Page Start: 148
• Page End: 154
• Publication Date: 2016-03-15
• Subjects: Ovarian cancer -- Outcomes research -- Epidemiology -- Outreach; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.3109/07357907.2016.1139716
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: Ovarian cancers diagnosed between 2000 and 2013 were examined and cases with and without endometriosis compared. Among 139 epithelial ovarian, there were 49 (35%) with endometriosis and 90 (65%) without endometriosis. Endometriosis associated ovarian cancers were more likely to be confined to the pelvis (54% vs. 9%, p < 0.0001) and lower grade (51% vs. 29%, p = 0.014). Younger age and earlier stage independently predicted the presence of endometriosis ( p = 0.0011 and p < 0.0001, respectively). Ovarian cancer patients with endometriosis had improved PFS and OS [(HR = 0.20; 95% CI, 0.09–0.43), (HR = 0.18; 95% CI, 0.04–0.81)], compared to patients without endometriosis; however, endometriosis had no independent prognostic significance.