Identifying high-risk adult AML patients: epigenetic and genetic risk factors and their implications for therapy. Issue 4 (2nd April 2016)

• Record Type: Journal Article
• Authors: Bret, Caroline; Viziteu, Elena; Kassambara, Alboukadel; Moreaux, Jerome
• Is Part Of: Expert review of hematology. Volume 9:Issue 4(2016)
• Page Start: 351
• Page End: 360
• Publication Date: 2016-04-02
• Subjects: Acute myeloid Leukemia -- Epigenetics -- Genetic -- Risk factors -- targeted treatment; Hematology -- Periodicals; 616.15005
• DOI: 10.1586/17474086.2016.1141673
• Languages: English
• ISSNs: 1747-4086

Abstract

ABSTRACT: Acute myeloid leukemia (AML) is a heterogeneous disease at molecular level, in response to therapy and prognosis. The molecular landscape of AML is evolving with new technologies revealing complex panorama of genetic abnormalities where genomic instability and aberrations of epigenetic regulators play a key role in pathogenesis. The characterization of AML diversity has led to development of new personalized therapeutic strategies to improve outcome of the patients.