Diabetes and Glucose Metabolism in Thalassemia Major: An Update. Issue 4 (2nd April 2016)

• Record Type: Journal Article
• Authors: De Sanctis, Vincenzo; Soliman, Ashraf T; Elsedfy, Heba; Pepe, Alessia; Kattamis, Christos; El Kholy, Mohamed; Yassin, Mohamed
• Is Part Of: Expert review of hematology. Volume 9:Issue 4(2016)
• Page Start: 401
• Page End: 408
• Publication Date: 2016-04-02
• Subjects: Thalassemia -- Iron overload -- Glucose homeostasis -- Treatment -- Magnetic resonance imaging -- Continuous glucose monitoring system; Hematology -- Periodicals; 616.15005
• DOI: 10.1586/17474086.2016.1136209
• Languages: English
• ISSNs: 1747-4086

Abstract

ABSTRACT: In patients with TM, uncontrolled iron overload has serious clinical consequences with considerable morbidity and mortality. Complications include liver damage, cardiac disease and endocrine dysfunction. Diabetes is an important complication of TM. The mechanisms of abnormal glucose homeostasis are complex and multifactorial. This review updates the current knowledge about glycemic abnormalities in TM patients and directs the attention to an early diagnosis and proper management