NMR-based metabolomics of prostate cancer: a protagonist in clinical diagnostics. (2nd June 2016)

• Record Type: Journal Article
• Authors: Kumar, Deepak; Gupta, Ashish; Nath, Kavindra
• Is Part Of: Expert review of molecular diagnostics. Volume 16:Number 6(2016)
• Page Start: 651
• Page End: 661
• Publication Date: 2016-06-02
• Subjects: Metabolomics -- prostate cancer -- NMR spectroscopy -- clinical intervention -- PET -- MRSI; Molecular diagnosis -- Periodicals; 616.0758205
• DOI: 10.1586/14737159.2016.1164037
• Languages: English
• ISSNs: 1473-7159

Abstract

ABSTRACT: Advances in the application of NMR spectroscopy-based metabolomic profiling of prostate cancer comprises a potential tactic for understanding the impaired biochemical pathways arising due to a disease evolvement and progression. This technique involves qualitative and quantitative estimation of plethora of small molecular weight metabolites of body fluids or tissues using state-of-the-art chemometric methods delivering an important platform for translational research from basic to clinical, to reveal the pathophysiological snapshot in a single step. This review summarizes the present arrays and recent advancements in NMR-based metabolomics and a glimpse of currently used medical imaging tactics, with their role in clinical diagnosis of prostate cancer.