Reflex epileptic mechanisms in ictogenesis and therapeutic consequences. (3rd May 2016)

• Record Type: Journal Article
• Authors: Lin, Katia; Guaranha, Mirian; Wolf, Peter
• Is Part Of: Expert review of neurotherapeutics. Volume 16:Number 5(2016)
• Page Start: 573
• Page End: 585
• Publication Date: 2016-05-03
• Subjects: Reflex seizures -- system epilepsies -- ictogenesis -- epileptic networks -- non-pharmacological epilepsy treatment -- epilepsy treatment strategies; Neuropharmacology -- Periodicals; 615.7805
• DOI: 10.1586/14737175.2016.1169174
• Languages: English
• ISSNs: 1473-7175

Abstract

ABSTRACT: Recent studies of reflex epileptic mechanisms in human epilepsy using advanced methods of neurophysiology and functional neuroimaging have contributed much to elucidate pathophysiological processes of seizure generation. Whereas in lesional focal epilepsies reflex mechanisms usually relate directly to the anatomical focus, in system epilepsies they have helped to define which functional anatomical systems serving physiological function are recruited by the ictogenic mechanisms. Reflex epileptic seizures can often be prevented by avoidance or modification of triggers or by prophylactic benzodiazepine administration. Surgical options apply to focal cases. According to restricted experiences with pharmacotherapy, without controlled studies and little information on new AEDs, reflex seizures in system epilepsies appear to respond best to valproic acid and in focal epilepsies, to carbamazepine.