Comparison of efficacy and safety of taking miglitol dissolved in water during a meal and taking a miglitol tablet just before a meal in patients with type 2 diabetes. (2nd May 2016)

• Record Type: Journal Article
• Authors: Shibata, Eriko; Aoki, Kazutaka; Tajima, Kazuki; Taguri, Masataka; Terauchi, Yasuo
• Is Part Of: Expert opinion on pharmacotherapy. Volume 17:Number 7(2016)
• Page Start: 889
• Page End: 894
• Publication Date: 2016-05-02
• Subjects: Miglitol -- liquid formulation -- tablet formulation -- type 2 diabetes -- postprandial glucose; Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1517/14656566.2016.1159297
• Languages: English
• ISSNs: 1465-6566

Abstract

ABSTRACT: Objective: We compared the efficacy and safety of taking miglitol dissolved in water during a meal and taking a miglitol tablet just before a meal. Primary efficacy parameter is the area under the curve (AUC) for postprandial plasma glucose. Methods: Miglitol was administered according to three different intake schedules in each subject: intake schedule A, no miglitol; intake schedule B, administration of miglitol (50 mg) just before breakfast; intake schedule C, dissolving miglitol (50 mg) in water and taking it just before (1/3), during (1/3), and just after breakfast (1/3). Blood samples were collected at 0, 30, 60, 120, and 180 min after breakfast. Results: The AUCs for plasma glucose, insulin, and total glucose-dependent insulinotropic polypeptide (GIP) were significantly lower for intake schedules B and C, compared with those for intake schedule A. The AUC for total glucagon like peptide-1(GLP-1) was higher for intake schedule C than for intake schedule A. The coefficient of variation (CV) of plasma glucose was significantly lower for intake schedule C than for intake schedules A and B. Conclusion: Taking miglitol dissolved in water was equivalent to taking a miglitol tablet. The CV of plasma glucose was significantly lower for the dissolved-dose regimen.