Role of hypothyroidism in obstructive sleep apnea: a meta-analysis. (2nd June 2016)

• Record Type: Journal Article
• Authors: Zhang, Mingpeng; Zhang, Weisan; Tan, Jin; Zhao, Minghui; Zhang, Qiang; Lei, Ping
• Is Part Of: Current medical research and opinion. Volume 32:Number 6(2016:Jun.)
• Page Start: 1059
• Page End: 1064
• Publication Date: 2016-06-02
• Subjects: Apnea -- hypopnea index -- epworth sleepiness scale -- hormonal replacement therapy -- hypothyroidism -- obstructive sleep apnea; Clinical medicine -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1185/03007995.2016.1157461
• Languages: English
• ISSNs: 0300-7995

Abstract

Abstract: Objective : This study evaluates the role of hypothyroidism in obstructive sleep apnea (OSA) by comparing the OSA indices in hypothyroid OSA (OSA-HYPOT) with euthyroid OSA (OSA-EUTHY) patients.Methods : After literature search in several electronic databases and selection of studies by following eligibility criteria, meta-analyses of mean differences/standardized mean differences were performed to compare OSA indices at the time of diagnosis between OSA-HYPOT and OSA-EUTHY patients. Metaregression analyses were carried out to examine the relationship between age, BMI, sample size, and gender vs OSA indices in OSA-HYPOT patients.Results : Twelve studies and five case reports recruiting 192 OSA-HYPOT and 1423 OSA-EUTHY patients were included in the meta-analysis. Prevalence (mean ± SD) of clinical hypothyroidism in OSA patients was 8.12 ± 7.13% and that of subclinical hypothyroidism 11.07 ± 8.49%. Apnea–Hypopnea Index, time of sleep with oxygen desaturation <90%, and Epworth Sleepiness Scale were significantly higher in the OSA-HYPOT patients at diagnosis, whereas there was no significant difference in arousal index, respiratory disturbance index and sleeping efficiency between OSA-HYPOT and OSA-EUTHY patients. Body mass index was positively associated with Apnea–Hypopnea Index in OSA-HYPOT patients.Conclusions : Hypothyroidism is found to be associated with severity of OSA. However, obesity can be a confounder in the outcomes observed herein.