Failure of combination therapy for Staphylococcus aureus bone infection: a case of in vivo selection with resistance to rifampicin and fusidic acid. Issue 9 (1st September 2016)

• Record Type: Journal Article
• Authors: Aubin, Guillaume G.; Bémer, Pascale; Guillouzouic, Aurélie; Launay, Elise; Geffroy, Loïc; Touchais, Sophie; Corvec, Stéphane
• Is Part Of: Infectious diseases. Volume 48:Issue 9(2016:Sep.)
• Page Start: 699
• Page End: 702
• Publication Date: 2016-09-01
• Subjects: Biofilm -- bone -- fusA -- resistance -- rpoB -- Staphylococcus aureus; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; 616.9
• DOI: 10.1080/23744235.2016.1183815
• Languages: English
• ISSNs: 2374-4235

Abstract

Abstract: Staphylococcus aureus is one of the main etiologies of bone and device-related infections. Treatment of these orthopedic infections combines mostly rifampicin with other antibiotics. The recurrence or failure rate after fusidic acid/rifampicin treatment remains low (<10%). We discuss here a case of antibiotic treatment failure for Staphylococcus aureus bone infection with in vivo selection of rifampicin and fusidic acid resistance. We also report a new mutation in fusA gene involved in fusidic acid resistance.