Transcription-induced DNA supercoiling: New roles of intranucleosomal DNA loops in DNA repair and transcription. Issue 3 (26th May 2016)

• Record Type: Journal Article
• Authors: Gerasimova, N. S.; Pestov, N. A.; Kulaeva, O. I.; Clark, D. J.; Studitsky, V. M.
• Is Part Of: Transcription. Volume 7:Issue 3(2016)
• Page Start: 91
• Page End: 95
• Publication Date: 2016-05-26
• Subjects: chromatin -- DNA repair -- DNA supercoiling -- elongation -- intermediates -- intranucleosomal DNA loops -- mechanism -- nucleosome -- RNA polymerase II -- single strand DNA breaks -- structure -- transcription; Genetic transcription -- Periodicals; 572.8
• DOI: 10.1080/21541264.2016.1182240
• Languages: English
• ISSNs: 2154-1264

Abstract

ABSTRACT: RNA polymerase II (Pol II) transcription through chromatin is accompanied by formation of small intranucleosomal DNA loops. Pol II captured within a small loop drives accumulation of DNA supercoiling, facilitating further transcription. DNA breaks relieve supercoiling and induce Pol II arrest, allowing detection of DNA damage hidden in chromatin structure.