A parallel group randomised open blinded evaluation of Acceptance and Commitment Therapy for Depression After Psychosis: A Pilot Trial Protocol (ADAPT). Issue 2 (2nd April 2016)

• Record Type: Journal Article
• Authors: Gumley, Andrew; White, Ross; Briggs, Andy; Ford, Ian; Barry, Sarah; Stewart, Corinna; Beedie, Sara; Clarke, Caoimhe; MacLeod, Rachel; Lidstone, Emma; Nam, Julian; McLeod, Hamish
• Is Part Of: Psychosis. Volume 8:Issue 2(2016)
• Page Start: 143
• Page End: 155
• Publication Date: 2016-04-02
• Subjects: schizophrenia -- depression -- randomised controlled trial -- pilot -- Acceptance and Commitment Therapy; Psychoses -- Periodicals; Psychotic Disorders -- therapy; Psychotic Disorders -- etiology; Psychoses; Periodicals; Periodicals; 616.89005
• DOI: 10.1080/17522439.2015.1100669
• Languages: English
• ISSNs: 1752-2447

Abstract

Abstract : Background: Depression is one of the major contributors to poorer quality of life among individuals with psychosis and schizophrenia. Aims: This study protocol was designed as a pilot trial to determine the parameters of a larger, definitive pragmatic multi-centre randomised controlled trial of Acceptance and Commitment Therapy for depression after psychosis (ACTdp) for individuals with a diagnosis of schizophrenia who also meet diagnostic criteria for major depression. Methods: The study protocol was registered before initiating recruitment and was designed as a Parallel-group Randomised Open Blinded Evaluation (PROBE) comparing ACTdp plus standard care (SC) or SC alone. Participants were required to meet DSM-IV-TR criteria for schizophrenia and major depression (confirmed by Structured Clinical Interview for DSM/SCID-I & Calgary Depression Scale for Schizophrenia; score > 7). Blinded follow-ups are undertaken at 5 months (end of treatment) and at 10 months (5 months post treatment). Implications: The pilot aims to establish the basis for a larger-scale multi-centre randomised controlled trial of ACTdp. The most important study outcomes that will provide the basis of informing progression to a full trial are identified a priori as Population, Intervention, Control and Outcomes (PICO).